Psychiatrist Henri Lacombe heads the National Institute of Mental Health. Day after day, his mission is to ease the suffering of his patients. His spouse, Anne Beaulieu, is a consulting psychologist in a private clinic. The two deal with the ups and downs of everyday family life with their two children, Marine and William. Henri's world changes when Anne does not show up at the restaurant where they are to meet. What happened to her?

Back from Asia, Henri Lacombe wanted to rebuild his life by reuniting with his family and his patients at the Institute. Simone Vallier investigates the murders of young women and calls on the expertise of the psychiatrist. This collaboration launches them into a dangerous common quest. Cerebrum transports us to the complex and fascinating world of mental health, where psychological suspense and police investigation are skillfully intertwined.