Due to an enormous financial scam, in which they lost all their savings and reputation, the first season follows Diane Lockhart and her goddaughter Maia Rindell as they are forced to join Lucca Quinn at one of Chicago's preeminent law firms.

The Chicago murder rate is on the rise, and amidst the insanity, Diane, Lucca, Maia, and the rest of the law firm find themselves under psychological assault when a client at another firm kills his lawyer for overcharging. Following a copycat murder, the firm begins to look at its own clients suspiciously. Meanwhile, Diane battles with a new partner at the firm, Maia becomes tougher after her parents' scandal puts her on trial, and Lucca is brought back into the orbit of Colin.

The world went crazy in the second season, and now, in season 3, the resistance does. Diane Lockhart tries to figure out whether you can resist a crazy administration without going crazy yourself, while Adrian Boseman and Liz Reddick-Lawrence struggle with a new post-factual world where the lawyer who tells the best story triumphs over the lawyer with the best facts. Meanwhile, Lucca Quinn balances a new baby with a new love, and Maia Rindell finds a new Mephistopheles in Roland Blum, a lawyer who is corruption incarnate.

Season four finds Reddick, Boseman and Lockhart navigating a very different landscape. After their defeats in the previous season, Reddick, Boseman and Lockhart was forced to accept an offer by a huge multinational law firm, STR Laurie, to become a small subsidiary.

In the fifth season, Diane is forced to question whether it’s appropriate for her to help run an African American law firm with Liz when the firm loses two top lawyers. Meanwhile, Marissa and the firm become entangled with Hal Wackner, a regular Chicagoan who decides to open his own courtroom in the back of a copy shop.

The final season has Diane feeling like she’s going crazy, struggling with an uneasy sense of déjà vu, with everything from Roe v. Wade, to voting rights, to Cold War aggressions returning. Meanwhile, the lawyers of Reddick & Associates wonder if the violence that they see all around them points to an impending civil war.