The second season begins in North Carolina, where Mike and Frank comb through a collector's abandoned outbuildings and find a 1950 Studebaker. As their junkyard journeys continue, the pickers rummage through ramshackle school buses, a burned storage building, forgotten barns, salvage yards, and rust heaps in search of what they call "good junk." They come across an item they've never seen before, place bets on what it actually is, and get a surprising assessment from the appraiser. They encounter a mother and daughter who catch the picking bug and give the guys a run for their money. And with nerves of steel, they try to strike deals with people who are often reluctant to part with their possessions. Meanwhile, back in Iowa, Danielle Colby Cushman holds down the fort at Antique Archaeology.

The fourth season opens with a truly historic find: a 65-million-year-old dinosaur bone found in Mississippi. Purchased for a mere $450, the bone is priceless, according to the paleontology museum curator who appraises it. In subsequent episodes, the duo will "pick" a speedy cycle car, crafted from the wing tank of a WWII-era plane; the work of iconic painter Norman Rockwell; a 350-pound taxidermy African elephant head, which they ultimately swap in exchange for a vintage photo booth and jukebox; and two coin-operated "peek-a-boo" strip poker machines from the 1950's. As Mike and Frank demonstrate, no two treasures, no two adventures and no two episodes are alike.

In the new season, Mike and Frank travel on a European adventure as they pick their way thru Italy and England. In Europe, the guys struggle with the language barrier and have to rely on translators who barely speak English to negotiate their deals. They find rare cars and motorcycles that you won't find back in the states but they aren't able to seal every negotiation since they have to factor in the exchange rate between Euros and dollars, and the cost of shipping everything back home. Back in the states, Mike and Frank will once again haggle over a slew of interesting historic items and meet quirky and interesting characters. From rare Bonnie and Clyde memorabilia to a Bass Guitar that may have belonged to Bill Black, a legendary musician who played with Elvis, to a typewriter that supposedly was lent to Albert Einstein. Meanwhile, in Iowa, Danielle Colby is overseeing the Antique Archaeology store expansion and is holding down the fort.

Mike and Frank continue their mission to recycle America by rescuing forgotten relics and giving them a new lease on life, while learning a thing or two about American history along the way. In the season opener, Dan Auerbach of the Black Keys shows interest in a vintage Chet Atkins Gretsch guitar that Mike stumbled across in South Carolina. In upcoming episodes, Mike and Frank cover new territory, picking in New Mexico for the first time ever. It wouldn't be American Pickers without amazing classic cars, and this season features two particularly rare ones: a 1954 Red Nash Healey Coupe and a 1954 Grey Nash Healey Coupe. Also coming up, the guys find a building chock full of Star Wars memorabilia including a life-sized Storm Trooper and Yoda, causing Frank to geek out. A lot is at stake when Frank makes a big bet with Mike: If Mike can down six dozen oysters then Frank has to shave his beard.

Frank and Mike tour the country in search of more fascinating finds, traveling from a Texas ranch to a Northern California artist's hideout.